HALC: High throughput algorithm for long read error correction

Journal|[J]BMC BioinformaticsVolume 18, Issue 1. 2017.

作者: Ergude Bao; Lingxiao Lan

作者背景: School of Software Engineering, Beijing Jiaotong University; University of California, Riverside

DOI: 10.1186/s12859-017-1610-3

全部来源

dx.doi.org

Abstract / 摘要

原文

MT机译

The third generation PacBio SMRT long reads can effectively address the read length issue of the second generation sequencing technology, but contain approximately 15% sequencing errors. Several error correction algorithms have been designed to efficiently reduce the error rate to 1%, but they discard large amounts of uncorrected bases and thus lead to low throughput. This loss of bases could limit the completeness of downstream assemblies and the accuracy of analysis.

收起Key Words / 关键词

PacBio long reads; Error correction; Throughput

Indexed by / 核心评价

EI; Scopus; SCI; WAJCI; MEDLINE; INSPEC; PMC;

References / 参考文献（引用的文献）：本文研究的参考依据

国际期刊

共27条

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