matlab在医学中的应用

1) 介绍机能核磁共振成像技术( fMRI: functional Magnetic Resonance Imaging)２ ) 介绍 MATLAB上开发的 fMRI分析软件SPM (Statistical Parametric Mapping)fMRI Setup – what it really looks like!Magnet SafetyThe whopping strength of the magnet makes safety essential.Things fly – Even big things!Screen subjects carefullyWere you ever a soldier? Make sure you and all your students & staff are aware of hazzards!Develop strategies for screening yourself every time you enter the magnet!fMRI SetupfMRI Experiment Stages: Prep1) Prepare subject• Consent • Safety screening• Instructions2) Shimming • putting body in magnetic field makes it non-uni• adjust 3 orthogonal weak magnets to make magnetic field as homogenous as possible3) SagittalsTake images along the midline to use to plan slicesfMRI Experiment Stages: Anatomical4) Take anatomical (T1) images• high-resolution images (e.g., 1x1x2.5 mm)• 3D data: 3 spatial dimensions, sampled at one point in time• 64 anatomical slices takes ~5 minutesSlice Thicknesse.g., 6 mmNumber of Slicese.g., 10SAGITTAL SLICE IN-PLANE SLICEField of View (FOV)e.g., 19.2 cmVOXEL(Volumetric Pixel)3 mm3 mm6 mmSlice TerminologyMatrix Sizee.g., 64 x 64In-plane resolutione.g., 192 mm / 64= 3 mmfMRI Experiment Stages: Functional5) Take functional (T2*) images• images are indirectly related to neural activity• usually low resolution images (3x3x5 mm)• all slices at one time = a volume (sometimes also called an image)• sample many volumes (time points) (e.g., 1 volume every 2 seconds for 150 volumes = 300 sec = 5 minutes)• 4D data: 3 spatial, 1 temporalfirst volume(2 sec to acquire)…