Windows Registry Editor Version 5.00
;                            视觉设置
[HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\VisualEffects]
"VisualFXSetting"=dword:00000000

以下两种办法刷新也无法立即生效。。但是手动设置能立即生效。。。由于以前做系统时把这个给去了 现在发现显示字体边缘模糊有锯齿。。。十分难堪。。。特此寻求解决方法。。
DllCall("user32.dll","int","SendMessageTimeout","hwnd",65535,"int",26,"int",0,"int",0,"int",0,"int",1000,"str","dwResult")

Do 
        ProcessClose("explorer.exe")
Until Not ProcessExists("explorer.exe")
Run("gpupdate /force","",@SW_HIDE)

#Include <WinAPI.au3>
WinActivate ("[CLASS:CabinetWClass]")
_WinAPI_PostMessage(ControlGetHandle("[CLASS:CabinetWClass]", "", "SysListView321"),256,116,0); 刷新我的电脑
_WinAPI_PostMessage(ControlGetHandle("[CLASSrogman]", "", "SysListView321"),256,116,0);刷新桌面

Func _Update_Explorer()
Local $bOld = Opt("WinSearchChildren", True)
Local $a = WinList("[CLASS:SHELLDLL_DefView]")
For $i = 0 To UBound($a) - 1
DllCall("user32.dll", "long", "SendMessage", "hwnd", $a[$i][1], "int", 0x111, "int", 28931, "int", 0)
Next
Opt("WinSearchChildren", $bOld)
EndFunc;==>_Update_Explorer

DllCall("shell32.dll", "none", "SHChangeNotify", "long", 0x8000000, "int", 0, "ptr", 0, "ptr", 0)

1、最有效的： 
结束explorer.exe，缺点时资源管理器被关，有些窗口被关，出现无任务栏桌面状态，虽然可以生效，但不推荐。

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Do
ProcessClose("explorer.exe") 
Until Not ProcessExists("explorer.exe")

2、调用SendMessageTimeout。效果不理想。

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DllCall("user32.dll","int","SendMessageTimeout","hwnd",65535,"int",26,"int",0,"int",0,"int",0,"int",1000,"str","dwResult")

3、调用组策略刷新设置工具，测试无效

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Run("gpupdate /force",@SystemDir)

4、又一刷新注册表的API，非常强捍。效果不错

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DllCall("shell32.dll", "none", "SHChangeNotify", "long", 0x8000000, "int", 0, "ptr", 0, "ptr", 0)

5、刷新桌面
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RunDll32.exe USER32.DLL,UpdatePerUserSystemParameters

6chinanewxp的函数，可以刷新注册表改文件图标后即时生效。

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MyUpdateREG()

Func MyUpdateREG()
Global Const $HWND_BROADCAST=0xFFFF
Global Const $WM_SETTINGCHANGE=0x1A
DLLCall("user32.dll","int","SendMessage","hwnd",$HWND_BROADCAST,"int",$WM_SETTINGCHANGE,"int","", "int", "")
EndFunc

测试了一下，直接用API搞定：
DllCall('USER32.DLL','dword','SystemParametersInfo','dword',75,'dword',1,'dword',2,'dword',0x1) 
留字备用！！！！