DBCO-C6-NHS ester，1384870-47-6二苯基环辛炔-碳6-琥珀酰亚胺酯仅用于科研,不用于人体和生产
英文名称：DBCO-C6-NHS ester
中文名称：二苯基环辛炔-碳6-琥珀酰亚胺酯
CAS No：1384870-47-6
分子式：C25H22N2O5
分子量：430.5
溶解性：DMF, DMSO, DCM, THF, Chloroform
纯 度：>95% (HPLC)
存 储：-20°C
用 途：仅用于科研,不用于人体和生产
结构式：
其它DBCO修饰剂列表：
名称：DBCO-NHS Ester MW：402.40
英文介绍：
DBCO-NHS Ester reacts with primary amines
This product is not recommended for labeling of proteins or any other biopolymers in aqueous buffers due to poor aqueous solubility.
名称：Photocleavable DBCO-NHS ester MW:945.96
英文介绍：
An amine-reactive, photocleavable labeling reagent.
Photocleavable DBCO-NHS ester reagent contains an amine reactive group linked to DBCO moiety through a spacer arm containing a photocleavable moiety. Molecules jointed by the copper-free click reaction can be efficiently photoreleased, typically >90% in 5-25 minutes using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2).
名称: DBCO-C6-NHS Ester MW:430.45
英文介绍：
An activated ester with extended 6-carbon atom long spacer.
DBCO-NHS Ester reacts with primary amines (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form covalent bonds. Extended 6-carbon spacer arm is beneficial for some application. This reagent has limited shelf life; however, corresponding acid and its derivatives are found to be stable over long period of time. DBCO-Sulfo-NHS-Ester, a water-soluble version of this product is also available for labeling experiments where the presence of organic solvents is highly undesirable.
名称：DBCO-PEG5-NHS Ester MW:693.74
英文简介：
An amine-reactive labeling reagent with enhanced water stability and solubility.
DBCO-PEG5-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the labeled molecule, thus reducing aggregation of labeled proteins stored in solution. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary azide-containing molecules.
名称：DBCO-PEG4-NHS Ester MW:649.68
英文简介：
An amine-reactive labeling reagent with enhanced water solubility provided by a PEG4 spacer.
DBCO-PEG4-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the labeled molecule, thus reducing aggregation of labeled proteins stored in solution. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary azide-containing molecules.
名称：DBCO-Sulfo-NHS Ester MW:532.50
英文简介：
A water-soluble reagent for labeling antibodies, proteins and other molecules containing primary amines.
DBCO-Sulfo-NHS-Ester enables simple and efficient labeling of antibodies, proteins and any other primary amine-containing macromolecules with DBCO moiety. This reagent is water-soluble, enabling labeling to be performed in the absence of organic solvents such as DMSO or DMF for applications that cannot tolerate solvents or are complicated by their inclusion. Specific labeling of cell surface proteins is another common application for these uniquely water-soluble and membrane impermeable reagents.
名称：DBCO-Acid MW:305.11
英文简介：
DBCO-Acid is an amine reactive, non-activated cyclooctyne building block.
The use of strained cyclooctynes instead of terminal alkynes allows for overcoming a major drawback of copper-catalyzed azide-alkyne cycloaddition (CuAAC) - the need for the toxic copper catalyst. The ring strain in cyclooctynes, such as DBCO-Acid makes them highly reactive in the cycloaddition reaction. This reaction was termed as the strain-promoted alkyne-azide cycloaddition (SPAAC) or copper-free click reaction and has been widely used for bioconjugation and for labeling living cells and living animals.
名称：DBCO-C6-Acid MW:333.83
英文简介：
An analog of DBCO-Acid with improved stability and solubility in commonly used organic solvents.
DBCO reagents, also known as ADIBO or DIBAC are routinely used building blocks for synthesis of complex molecules to be used in Cu-free ligation applications.
Using DBCO-C6-Acid primary or secondary amines can be easily functionalized with DBCO moiety in the presence of activators (e.g. EDC, or HATU) through a stable amide bond. A longer carbon spacer arm improves stability and solubility of this reagent in commonly used organic solvents.
名称：DBCO-PEG5-Acid MW:596.67
英文简介：
An amine-reactive building block with enhanced stability and solubility in aqueous media.
DBCO-PEG5-Acid is a polyethylene glycol-containing reagent with terminal carboxylic acid (–COOH) that can be reacted with primary or secondary amine groups in the presence activators (e.g. EDC) forming a stable amide bond. The PEG spacer arm is hydrophilic and provides greater solubility to labeled molecules compared to reagents having only hydrocarbon spacers. The PEG spacer arm also gives the reagent a long and flexible connection to minimize steric hindrance involved with reacting with complementary azido-modified molecules.
名称：DBCO-PEG4-Acid MW:552.62
英文简介：
An amine-reactive building block with enhanced solubility in aqueous media.
DBCO-PEG4-Acid is a polyethylene glycol-containing reagent with terminal carboxylic acid (–COOH) that can be reacted with primary or secondary amine groups in the presence activators (e.g. EDC) forming a stable amide bond. The PEG spacer arm is hydrophilic and provides greater solubility to labeled molecules compared to reagents having only hydrocarbon spacers
名称：DBCO-PEG4-4-Formylbenzoate MW:655.77
英文简介：
A heterobifunctional reagent for labeling aminooxy-containing compounds.
DBCO-PEG4-4-Formylbenzoate reacts specifically and efficiently with an aminooxy group at pH 4-5 to form a covalent oxime bond. The oxime ligation with aromatic aldehydes is highly chemoselective and is compatible with other functional groups present in peptides or biomolecules. An aniline catalysis can be used to activate aromatic aldehyde towards an aminooxy group and greatly enhance the rate of ligation reaction.
名称：ThioLinker-DBCO
英文简介：
A unique, water-soluble, bis-alkylating reagent that allows for site-specific labeling of antibodies under mild aqueous conditions.
The traditional sulfhydryl labeling chemistry cleaves disulfide bridges and leaves them in “open form”, which may compromise the stability and function of an antibody or other proteins. ThioLinkerTM-DCBO re-bridges the disulfide bond, and enhances the structural stability of the protein. In addition, conjugates prepared with ThioLinkerTM reagents benefits from reduced heterogeneity and better stability.
名称：DBCO-Maleimide MW:427.75
英文简介：
A short-length, sulfhydryl-reactive labeling reagent that contains a short hydrocarbon spacer.
DBCO-Maleimide enables simple and efficient incorporation of DBCO moiety onto cysteine-containing peptides or other thiol-containing molecules. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form stable thioether bonds. A short spacer arm adds minimal mass to modified molecules (427.4 daltons).
名称：DBCO-PEG4-Maleimide MW:674.74
英文简介：
A mid-length, sulfhydryl-reactive labeling reagent with enhanced water solubility provided by a PEG4 spacer.
DBCO-PEG4-Maleimide enables simple and efficient incorporation of DBCO moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the labeled molecule, thus reducing aggregation of labeled proteins stored in the solution. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary azide-containing molecules.
名称：Bis-sulfone-PEG4-DBCO MW：1006.19
英文简介：
A bis-alkylating labeling reagent used to create conjugates with enhanced structural stability.
Bis-sulfone-PEG4-DBCO enables site-specific incorporation of DBCO moiety onto antibodies to form well defined conjugates. Unlike conjugates prepared through conventional, maleimide-based labeling chemistry that leaves disulfide bridges in “open form” and produces a heterogeneous mixture labeled species with DAR 1-8, conjugates prepared with bis-sulfone reagents benefits from reduced heterogeneity and enhanced stability.
名称：Bis-sulfone-PEG3-Azide MW:700.82
英文简介：
A bis-alkylating labeling reagent used to create well-defined conjugates with enhanced structural stability.
Bis-sulfone-PEG3-Azide enables site-specific incorporation of an azide group onto antibodies to form well defined conjugates. Unlike conjugates prepared through conventional, maleimide-based labeling chemistry that leaves disulfide bridges in “open form” and produces a heterogeneous mixture labeled species with DAR 1-8, conjugates prepared with bis-sulfone reagents benefits from reduced heterogeneity and enhanced stability.
名称：DBCO-PEG4-DBCO MW:854.92
英文简介：
An azide-to-azide homobifunctional cross-linker with a hydrophilic PEG4 spacer arm.
DBCO-PEG4-DBCO reacts specifically and efficiently with an azide group (e.g., a side chain of L-azidohomoalanine) to form a stable triazole moiety.
名称：TCO-PEG12-DBCO
英文简介：
An azide-to-tetrazine heterobifunctional cross-linker with a hydrophilic PEG12 spacer arm.
Heterobifunctional reagents are used for converting azido-containing biomolecules into TCO-modified biomolecules. TCO-PEG12-DBCO can serve as a heterobifunctional azide-to-tetrazine cross-linker for covalently linking azido- and tetrazine-modified peptides or biopolymers. The PEG12 spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary reagent.
名称：Methyltetrazine-DBCO
英文简介：
A water-soluble azide-to-TCO heterobifunctional crosslinker.
Heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents. Tetrazine-DBCO can serve as a heterobifunctional azide-to-TCO cross-linker for covalently linking azido- and TCO-modified peptides or biopolymers.
名称：Tetrazine-PEG12-DBCO
英文简介：
An azide-to-TCO heterobifunctional crosslinker with a hydrophilic PEG12 spacer arm.
Heterobifunctional reagents used for converting azido-containing peptides or protein into tetrazine-modified peptides or protein without the need for catalyst or axillary reagents. Tetrazine-PEG12-DBCO can serve as a heterobifunctional azide-to-TCO cross-linker for covalently linking azido- and TCO-modified peptides or biopolymers.
以上信息均由陕西新研博美生物科技有限公司提供技术支持
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