三、代表性科研成果：

[1]   Hongjie Wu, Kun Wang, Liyao Lu, Qiang Lyu, Min Jiang,A Deep Conditional Random Field Approach to Transmembrane Topology Prediction and Application to GPCR Three-Dimensional Structure Modeling, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2016: publish online http://doi.ieeecomputersociety.org/10.1109/TCBB.2016.2602872

[2]   Hongjie Wu, Chengyuan CAO,  Xiaoyan XIA,  Qiang LÜ, Unified Deep Learning Architecture for Modeling Biology Sequence, IEEE/ACM Transactions on Computational Biology and Bioinformatics(SCI), 2017: Accept

[3]   Hongjie Wu, Haiou Li, Min Jiang, Cheng Chen, Qiang Lv, and Chuang Wu, “Identify High-Quality Protein Structural Models by Enhanced -Means,” BioMed Research International, vol. 2017, Article ID 7294519, 9 pages, 2017. doi:10.1155/2017/7294519

[4]   Hongjie Wu, Chuang Wu, Chen Cheng, Longfei Song, and Min Jiang ,A Parallel Multiple K-Means Clustering and Application on Detect Near Native Model, Intelligent Computing Theories and Application. Springer International Publishing, 2016.

[5]   Wang K, Wu H, Lu W, et al. Predicting Helix Boundaries of α-Helix Transmembrane Protein with Feedback Conditional Random Fields[M]//Intelligent Computing Theories and Methodologies. Lecture Notes in Computer Science, vol. 9225 ,pp 730-736, 2015

[6]   Lu W, Fu B, Wu H, et al. CRF-TM: A Conditional Random Field Method for Predicting Transmembrane Topology[M]//Intelligence Science and Big Data Engineering. Big Data and Machine Learning Techniques. Lecture Notes in Computer Science ,Volume 9243 , pp 529-537, 2015.

[7]吴宏杰，吕强，权丽君，陈荣，陈沙沙，李海鸥，钱培德.GPCR跨膜螺旋的结构拓扑建模及其预测方法.计算机学报，2013，10：2168—2178(2013年度中国计算机大会评出的两篇优秀论文之一, 145篇录用，其中优秀2篇)

[8]吴宏杰，吕强，吴进珍，黄旭，罗小虎，钱培德.从头预测蛋白质骨架的一种并行蚁群方法及其在CASP8/9中应用.中国科学F辑：信息科学，2012, 42(8 ): 1034–1048

[9]   Hongjie Wu, Qiang Lü,  Quan Lijun, Peide Qian,PatGPCR: A Multitemplate Approach for improving 3D Structure Prediction of Transmembrane Helices of G-protein-coupled Receptors, Computational & Mathematical Methods in Medicine, 2013, 2013(1):151-164

[10] Hongjie Wu, Qiang Lü, Lingyun Yang, Zhonglan Luan,Peide Qian,Xiaoyan Xia ,CoREF: A Combined Refinement Approach for GPCRs Backbone Flexibility, Biomedical Engineering :Applications, Basis and Communications, Volume 25, Issue 06, December 2013,SCI

[11]吴宏杰，吕强， 唐剑峰，钱培德.一种序列相关支持向量机的β桶状跨膜蛋白预测方法.计算机科学2012,39(8):252-255