方法一: 1 int nodeIndex = 0;
 2         bool nodeChanged = false;
 3
 4         //右键点击，就进入修改状态
 5         private void treeView1_NodeMouseClick(object sender, TreeNodeMouseClickEventArgs e)
 6         {
 7             if (e.Button == MouseButtons.Right)
 8             {
 9                 e.Node.BeginEdit();
10             }
11         }
12
13         private void treeView1_AfterLabelEdit(object sender, NodeLabelEditEventArgs e)
14         {
15             nodeIndex = e.Node.Index;
16             nodeChanged = true;
17
18             e.Node.EndEdit(true );
19         }
20
21         private void treeView1_NodeMouseHover(object sender, TreeNodeMouseHoverEventArgs e)
22         {
23             if (nodeChanged == true)
24             {
25                 //在这里保存数据到数据库
26                 MessageBox.Show(treeView1.Nodes[nodeIndex].Text);
27
28                 nodeChanged = false;
29             }
30         }

方法二:MouseClick和AfterLabelEdit的使用，treeView1.LabelEdit = true;这句不可缺少：

1 public Form1()
 2 {
 3     InitializeComponent();
 4     this.Load+=new EventHandler(Form1_Load);
 5     treeView1.MouseClick+=new MouseEventHandler(treeView1_MouseClick);
 6     treeView1.AfterLabelEdit+=new NodeLabelEditEventHandler(treeView1_AfterLabelEdit);
 7 }
 8
 9 private void Form1_Load(object sender, EventArgs e)
10 {
11     for (int i = 0; i < 10; i++)
12     {
13         treeView1.Nodes.Add("tv" + i.ToString());
14         treeView1.Nodes[i].Nodes.Add("tvc"+i.ToString());
15     }
16     treeView1.LabelEdit = true;//不可缺少
17 }
18
19 private void treeView1_MouseClick(object sender, MouseEventArgs e)
20 {
21     TreeView tv=(TreeView)sender;//获取treeview
22     if (e.Button == MouseButtons.Right)//判断是否鼠标右键
23     {
24         if (tv.SelectedNode != null)//判断是否存在选择节点
25             tv.SelectedNode.BeginEdit();
26     }
27 }
28 private void treeView1_AfterLabelEdit(object sender, NodeLabelEditEventArgs e)
29 {
30     string newTxt = e.Label;//获取新文本
31     //string id = e.Node.Text;//获取原来的文本
32
33     //进行你的更新操作
34
35 }